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  1. IGB
  2. IGBF-3462

Even Expression failure in EBSEQ-HMM

    Details

    • Type: Task
    • Status: Closed (View Workflow)
    • Priority: Major
    • Resolution: Done
    • Affects Version/s: None
    • Fix Version/s: None
    • Labels:
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      Description

      EBSEQ-HMM should be able to predict whether gene increase or decrease over time using a HMM.

      And it does this well!
      BUT it should also be able to identify when states go from "Even expression" to high or low.

      And I can't seem to detect any genes that do this.
      Example:

      "c..Up.Up.Up....14...Down.Up.Up....40...Up.Down.Up....169...Down.Down.Up....59.."
      "Up-Up-Up" 14
      "Down-Up-Up" 40
      "Up-Down-Up" 169
      "Down-Down-Up" 59
      "Up-Up-Down" 13
      "Down-Up-Down" 207
      "Up-Down-Down" 32
      "EE-Up-Up" 0
      "Up-EE-Up" 0
      "EE-EE-Up" 0
      "Down-EE-Up" 0
      "EE-Down-Up" 0
      "Up-Up-EE" 0
      "EE-Up-EE" 0
      "Down-Up-EE" 0
      "Up-EE-EE" 0
      "Up-Down-EE" 0
      "EE-Up-Down" 0
      "Up-EE-Down" 0
      "Down-Down-Down" 3
      "Down-EE-EE" 0
      "EE-Down-EE" 0
      "Down-Down-EE" 0
      "EE-EE-Down" 0
      "Down-EE-Down" 0
      "EE-Down-Down" 0

      EE means even expression.
      They are all zero.
      And that happens in all 6 instances. Which is EXTREMELY unlikley.
      I am missing something.
      So this task is to figure out what I am missing!

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              • Assignee:
                robofjoy Robert Reid
                Reporter:
                robofjoy Robert Reid
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                • Created:
                  Updated:
                  Resolved: